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Longevity & AntiAging · Nutritional Medicine · Menopause · Andropause
Natural Bioidentical Hormonal Replacement · Complex Lipid Disorders · Stress Management
Human Growth Hormone
Two choices
Injectable
Human Growth Hormone (hGH)
(Still the Gold Standard)
(Only available after personal participation in one of our
AntiAging Programs here in Los Gatos, California)
Trans-D Tropin™
(Topical Cream)
(Our Current Highest Recommendation)
Recombinant Human Growth Hormone (hGH) I feel Invincible Again .
Background
Human growth hormone, secreted by the pituitary gland which is located in the center of the brain, peaks during adolescence when growth is most rapid. It is the primary hormone responsible for maintaining physical and mental health through tissue repair, healing, cell replacement, bone strength, brain function, enzyme production, integrity of the hair, nails and skin. By the age of 60 it is not uncommon to see declines in the order of 75% from more youthful levels.
Modern biotechnology has given us the ability to totally synthesize this remarkable hormone. The technique of production varies slightly from manufacturer to manufacturer. It is a complex protein molecule of 191 amino acids in length. Because of its size, complexity and stereoscopic configuration it cannot be taken orally, it must be injected. Twenty years ago GH was being used by weight lifters in massive doses from cadaveric sources. This was not without risk.
Today´s sources are pharmaceutically pure and completely safe. And, the doses we use today are in the very small physiological range.
Endocrinology
In order to understand the rationale of human growth hormone replacement vs Secretagogue augmentation refer to figure 1 below:
figure 1
The hypothalamus is the primitive site of the brain that sends either stimulating or inhibiting hormones to the pituitary. Growth hormone stimulating hormone (GHRH) tells the pituitary gland to secrete more growth hormone (GH) . On the other side, Growth Hormone Inhibiting Hormone (GHIH = Somatostatin) tells the pituitary gland to stop producing more GH.
Once the pituitary receives the positive stimulating signal it then secretes GH which in turn stimulates the liver to produce IGF-1 (Insulin-like growth factor 1) . This is the substance that is most commonly measured as a surrogate marker for GH output. Low IGF-1 = low GH. Somatomedin-C is just another name for IGF-1. Depending on the lab, it might be useful to identify both to clear up any confusion.
IGF-1 is also a more stable compound unlike true GH which has up to 5 spurts a day - the largest being just before sleep. If we were to measure GH directly it might show as too low or too high just because of the timing. Measuring IGF-1 circumvents this problem because of its more constant blood levels. Interestingly, both have distinct biochemical properties.
Once the IGF-1 levels are high enough, a feedback message is sent back to the pituitary and the hypothalamus to modulate further GH secretion. This is accomplished by secreting more Somatostatin which then slows down GH production.
You can see the intricate play between GHRH and Somatostatin as a servo mechanism in the brain to regulate just the right amount of GH release. This is the model for virtually all brain mediated hormonal control - the thyroid, adrenals, ovaries and testes.
Critical concept: As we age, GH output begins to fall off, whether by sluggishness of pituitary secretion or because of true GH decline. The outcome is the same: declining levels of GH which given rise to a plethora of symptoms which we know are the telltale signs of aging:
Loss of elasticity - thinning, sagging and wrinkled skin
Loss of bone strength - osteoporosis
Loss of Muscle strength - frailty and weakness
Increased adipose tissue - accumulation of fat
Loss of heart muscle contractility - heart failure
Less favorable lipid profile - increased cholesterol and decreased HDL
Loss of vigor and stamina
Loss of sexual powers and libido
Clinical Studies
It all started with the seminal Rudman study published in the New England Journal of Medicine (NEJM; 323:1-6 1990) . This pilot study divided 21 men 61-81 years old with plasma IGF-1 levels less than 350 iu per liter into two groups: 12 test subjects and 9 controls subjects. A six month base period of data collection preceded the six month test (GH injection) period.
The study showed an increase in lean muscle mass, a decrease in adipose fat tissue, and an increase in vertebral bone height. All test subjects had measurable increases in their IGF-1 blood values. The control group showed none of the above benefits.
To quote: The effects of six months of human growth hormone online body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during the 10 to 20 years of aging. In other words, regression of aging by 10-20 years.
(See also the Danish Jorgenson study)
Later Chien and Terry´s large group of over 1000 clinically treated individuals showed that lower dose, higher frequency administration (twice daily) is associated with virtually no side effects and substantial benefits:
Increased muscle strength, exercise, and body fat
Increase in skin elasticity, texture and tightness
Increased healing, flexibility and resistance
Increased sexual potency and frequency
Increased energy, emotional stability and memory
These results were part of a total hormonal replacement program and grading was based on each individuals own subjective response and evaluation. Uniformly, the responses showed improved scores in all categories based on the 212 participants´ own ratings.
Other studies since then have shown additional benefits:
Improved lipid picture - elevates HDL and lowers LDL
Effects on bone strength
Improved cardiovascular strength
Improved lung, kidney, liver, and spleen function
Improved sleep
Improved mental functioning and memory
Available forms
Human growth hormone is available from the following companies:
Upjohn Pharmacia: Genotropin
Eli Lilly: Humatrope
Novo Nordisk: Nordotropin
Serano: Saizen
Biotech General: not available in the U.S.
Secretagogues and Trans-D Tropin
Growth Hormone Stimulators
h we still offer and use recombinant hGH as the gold standard because it is controllable, powerful and able to confer the greatest rewards, it is, on the other hand, not for everyone.
It is injectable and, therefore, not for those with needle phobia.
It is expensive and, therefore, limited to those can afford to pay. This is not reimbursable on insurance plans.
It is not recommended for travel across international borders because of refrigeration problems and because of increased scrutiny you will face from border agents.
There is an alternative or, in some cases, an adjunct: topically applied (cream based) Trans-D Tropin.
These simulate the GHRH hormone as seen in figure 1 above. They are now available and more affordable.
Conclusion
Human growth hormone is one of the most powerful anti-aging tools we now have at our command. It affords us the ability to regress the effects of human aging. It is truly a rejuvenating agent, especially when combined with a full program of natural hormonal replacement and augmentation, proper nutrition, adequate supplementation and exercise. It is only available as an integral part of a comprehensive Rejuvenating Plan.
Growth hormone is never the program -- it is always part of a comprehensive and integrated approach.
We offer our patients either or both programs: Recombinant Growth Hormone (hGH) replacement therapy (see proviso above) and topical Trans-D Tropin. In many instances, they are quite complimentary for many of our more active clients. The results are remarkable.
The future is now and it´s available to you.
We invite your comments and questions.
It´s About time.
Longevity & AntiAging · Nutritional Medicine
Natural Hormonal Replacement · Complex Lipid Disorders · Stress Management
The statements made in this document have not been evaluated by the United States Food and Drug Administration. While AntiAging.com, and its agent, Los Gatos Longevity Institute, believes that the information contained in this document is true and accurate, all information is provided As is, with all faults, and AntiAging.com makes no representations or warranties, expressed or implied as to the usefulness, accuracy, completeness, feasibility, reliability or legality of the information contained herein.
hgh supplement
Longevity & AntiAging · Nutritional Medicine · Menopause · Andropause
Natural Bioidentical Hormonal Replacement · Complex Lipid Disorders · Stress Management
Human Growth Hormone
Two choices
Injectable
Human Growth Hormone (hGH)
(Still the Gold Standard)
(Only available after personal participation in one of our
AntiAging Programs here in Los Gatos, California)
Trans-D Tropin™
(Topical Cream)
(Our Current Highest Recommendation)
Recombinant Human Growth Hormone (hGH) I feel Invincible Again .
Background
Human growth hormone, secreted by the pituitary gland which is located in the center of the brain, peaks during adolescence when growth is most rapid. It is the primary hormone responsible for maintaining physical and mental health through tissue repair, healing, cell replacement, bone strength, brain function, enzyme production, integrity of the hair, nails and skin. By the age of 60 it is not uncommon to see declines in the order of 75% from more youthful levels.
Modern biotechnology has given us the ability to totally synthesize this remarkable hormone. The technique of production varies slightly from manufacturer to manufacturer. It is a complex protein molecule of 191 amino acids in length. Because of its size, complexity and stereoscopic configuration it cannot be taken orally, it must be injected. Twenty years ago GH was being used by weight lifters in massive doses from cadaveric sources. This was not without risk.
Today´s sources are pharmaceutically pure and completely safe. And, the doses we use today are in the very small physiological range.
Endocrinology
In order to understand the rationale of human growth hormone replacement vs Secretagogue augmentation refer to figure 1 below:
figure 1
The hypothalamus is the primitive site of the brain that sends either stimulating or inhibiting hormones to the pituitary. Growth hormone stimulating hormone (GHRH) tells the pituitary gland to secrete more growth hormone (GH) . On the other side, Growth Hormone Inhibiting Hormone (GHIH = Somatostatin) tells the pituitary gland to stop producing more GH.
Once the pituitary receives the positive stimulating signal it then secretes GH which in turn stimulates the liver to produce IGF-1 (Insulin-like growth factor 1) . This is the substance that is most commonly measured as a surrogate marker for GH output. Low IGF-1 = low GH. Somatomedin-C is just another name for IGF-1. Depending on the lab, it might be useful to identify both to clear up any confusion.
IGF-1 is also a more stable compound unlike true GH which has up to 5 spurts a day - the largest being just before sleep. If we were to measure GH directly it might show as too low or too high just because of the timing. Measuring IGF-1 circumvents this problem because of its more constant blood levels. Interestingly, both have distinct biochemical properties.
Once the IGF-1 levels are high enough, a feedback message is sent back to the pituitary and the hypothalamus to modulate further GH secretion. This is accomplished by secreting more Somatostatin which then slows down GH production.
You can see the intricate play between GHRH and Somatostatin as a servo mechanism in the brain to regulate just the right amount of GH release. This is the model for virtually all brain mediated hormonal control - the thyroid, adrenals, ovaries and testes.
Critical concept: As we age, GH output begins to fall off, whether by sluggishness of pituitary secretion or because of true GH decline. The outcome is the same: declining levels of GH which given rise to a plethora of symptoms which we know are the telltale signs of aging:
Loss of elasticity - thinning, sagging and wrinkled skin
Loss of bone strength - osteoporosis
Loss of Muscle strength - frailty and weakness
Increased adipose tissue - accumulation of fat
Loss of heart muscle contractility - heart failure
Less favorable lipid profile - increased cholesterol and decreased HDL
Loss of vigor and stamina
Loss of sexual powers and libido
Clinical Studies
It all started with the seminal Rudman study published in the New England Journal of Medicine (NEJM; 323:1-6 1990) . This pilot study divided 21 men 61-81 years old with plasma IGF-1 levels less than 350 iu per liter into two groups: 12 test subjects and 9 controls subjects. A six month base period of data collection preceded the six month test (GH injection) period.
The study showed an increase in lean muscle mass, a decrease in adipose fat tissue, and an increase in vertebral bone height. All test subjects had measurable increases in their IGF-1 blood values. The control group showed none of the above benefits.
To quote: The effects of six months of human growth hormone online body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during the 10 to 20 years of aging. In other words, regression of aging by 10-20 years.
(See also the Danish Jorgenson study)
Later Chien and Terry´s large group of over 1000 clinically treated individuals showed that lower dose, higher frequency administration (twice daily) is associated with virtually no side effects and substantial benefits:
Increased muscle strength, exercise, and body fat
Increase in skin elasticity, texture and tightness
Increased healing, flexibility and resistance
Increased sexual potency and frequency
Increased energy, emotional stability and memory
These results were part of a total hormonal replacement program and grading was based on each individuals own subjective response and evaluation. Uniformly, the responses showed improved scores in all categories based on the 212 participants´ own ratings.
Other studies since then have shown additional benefits:
Improved lipid picture - elevates HDL and lowers LDL
Effects on bone strength
Improved cardiovascular strength
Improved lung, kidney, liver, and spleen function
Improved sleep
Improved mental functioning and memory
Available forms
Human growth hormone is available from the following companies:
Upjohn Pharmacia: Genotropin
Eli Lilly: Humatrope
Novo Nordisk: Nordotropin
Serano: Saizen
Biotech General: not available in the U.S.
Secretagogues and Trans-D Tropin
Growth Hormone Stimulators
h we still offer and use recombinant hGH as the gold standard because it is controllable, powerful and able to confer the greatest rewards, it is, on the other hand, not for everyone.
It is injectable and, therefore, not for those with needle phobia.
It is expensive and, therefore, limited to those can afford to pay. This is not reimbursable on insurance plans.
It is not recommended for travel across international borders because of refrigeration problems and because of increased scrutiny you will face from border agents.
There is an alternative or, in some cases, an adjunct: topically applied (cream based) Trans-D Tropin.
These simulate the GHRH hormone as seen in figure 1 above. They are now available and more affordable.
Conclusion
Human growth hormone is one of the most powerful anti-aging tools we now have at our command. It affords us the ability to regress the effects of human aging. It is truly a rejuvenating agent, especially when combined with a full program of natural hormonal replacement and augmentation, proper nutrition, adequate supplementation and exercise. It is only available as an integral part of a comprehensive Rejuvenating Plan.
Growth hormone is never the program -- it is always part of a comprehensive and integrated approach.
We offer our patients either or both programs: Recombinant Growth Hormone (hGH) replacement therapy (see proviso above) and topical Trans-D Tropin. In many instances, they are quite complimentary for many of our more active clients. The results are remarkable.
The future is now and it´s available to you.
We invite your comments and questions.
It´s About time.
Longevity & AntiAging · Nutritional Medicine
Natural Hormonal Replacement · Complex Lipid Disorders · Stress Management
The statements made in this document have not been evaluated by the United States Food and Drug Administration. While AntiAging.com, and its agent, Los Gatos Longevity Institute, believes that the information contained in this document is true and accurate, all information is provided As is, with all faults, and AntiAging.com makes no representations or warranties, expressed or implied as to the usefulness, accuracy, completeness, feasibility, reliability or legality of the information contained herein.
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